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John Krasinski’s Mr. Fantastic appears in a canon that is, for all intents and purposes, completely separate from the events of the Marvel Cinematic Universe. With Strange and America Chavez having put the multiverse more or less back in order by the end of the film, these two dimensions no longer have anything to do with each other. That being said, the MCU has laid the groundwork for the Fantastic Four to get their own origin story that takes place in that same dimension.
Source: https://www.distractify.com/p/will-john-krasinski-play-mr-fantastic-again
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