However, like Anakin, Grievous made the fatal error of trusting Palpatine and Dooku. They repaid his trust by sabotaging his shuttle, which crashed and left Grievous near-death. The only way to save him? Even more cybernetic upgrades. Sound familiar?

Per the same Wookipedia report, Dooku lied to Grievous and informed him that a Jedi had been behind the sabotaged shuttle. Not only that, but Grievous’s actual organs rejected the new, cybernetic implants.

Source: https://www.distractify.com/p/why-does-general-grievous-cough