At the end of Season 5, Episode 2, Janine shares a forbidden chocolate with Esther, who, it seems, has finally come around to the fact that her place as a handmaid is unavoidable. But, unbeknownst to Janine, Esther somehow poisoned the chocolate. And even though Esther might die too, dying appears to be her goal.

Source: https://www.distractify.com/p/is-janine-dead-handmaids-tale