Over the years, Palpatine produced a series of “failed” clones he deemed unworthy and useless to him. There wasn’t anything wrong with many of the clones themselves, which is why one of them went rogue, had a daughter named Rey, and the course of the galaxy was changed forever.
What Palpatine needed was a clone who could harness the power of the Force, particularly the dark side of it. When he couldn’t make it happen with science, he pursued a more … natural approach.
Source: https://www.distractify.com/p/how-did-palpatine-survive