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In Last Seen Alive, Will Spann (played by Gerard) goes on an obsessive hunt for his wife Lisa (played by Jaimie Alexander) after she goes missing at a gas station. In The Vanishing, Jeff Harriman (Kiefer) goes on an obsessive hunt for his girlfriend Diane Shaver (Sandra) after she goes missing at a gas station.
Aside from the similar premises, both movies focus on the hero becoming more and more unhinged as he searches, and both have similar endings.
Source: https://www.distractify.com/p/is-last-seen-alive-a-remake
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