According to Screen Rant, Good Bones is filmed in Indianapolis, Ind. This is important to the show considering that Karen and Mina are from the area and they’re very hands-on when it comes to all the renovations on the show.
The two mainly focus on historic areas of the city, like Bates-Hendricks, Fountain Square, and Old Southside. Fountain Square is extra special to them because that’s where they began flipping houses years before the show began.
Source: https://www.distractify.com/p/where-is-good-bones-filmed