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In the past, Trey has gotten candid about how health issues have causes him to change the way that he does voices. Screen Rant noted that Trey had to change the way that he voiced Cartman at one point due to damage to his throat.
So, could it be throat damage, a Pro Tools, or some other unknown reason? Until the comedic legends at South Park confirm anything, it’s all purely speculation.
Check out new episodes of South Park airing Wednesdays at 8 p.m. EST on Comedy Central.