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According to IMDb, the cast and crew of Sister with a Secret filmed the movie in Los Angeles.
Ben Meyerson, an actor from Speed 2: Cruise Control, Knocked Up, and Funny People, directed the movie. His other directing credits include movies with similarly ominous titles, like Kidnapped by a Classmate, Deadly Daughter Switch, and A Bride’s Nightmare.
Dena Hysell-Cornejo and Isak Borg wrote Sister with a Secret after writing the scripts for the movies Ascent to Hell and Algorithm: BLISS.
Source: https://www.distractify.com/p/where-was-sister-with-a-secret-filmed
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