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According to Cleveland.com, the use of PES tests in the NFL is a very common occurrence and sometimes players are randomly selected to be tested.
The publication states that around 18,000 PED tests are administered each year and about 10,000 of those are a random selection of players. The other 8,000 tests fall into the league’s “Reasonable Cause” program, which basically keeps a list of players who have failed a PES test before and puts them at a higher likelihood of receiving another.
Source: https://www.distractify.com/p/what-is-a-pes-test-nfl
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